Mi Arbolito is located within one of the finest urban settings this region has to offer. Sitting at the north-west corner of Balboa Park and at the geographic center of Banker's Hill, this pedestrian-oriented urban site at Sixth Avenue and Upas Street faces the park, downtown, San Diego Bay and the Pacific Ocean.

Its urban context provides one with a myriad of San Diego’s finest museums, art galleries, theaters and restaurants, as well as the world famous San Diego Zoo; all within walking distance from Mi Arbolito. In close proximity is Hillcrest/Bankers Hill, one of San Diego’s most vibrant mixed-use neighborhoods containing excellent restaurants, shops, movie theaters and cabarets. Mi Arbolito is also centrally located to the Mission Valley Shopping District as well as to Little Italy and the Historic Gaslamp Quarter.

On Seventh Avenue, just around the corner from Mi Arbolito, is a quaint cul-de-sac of venerable houses, including the Marston Estate, several historic residences and notable homes by the early modernist architect Irving Gill.